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Journal of Gerontological Nursing, 2013;31(9):4–9
Published Online:https://doi.org/10.3928/0098-9134-20050901-04Cited by:164

Abstract

An Integrated Literature Review

ABSTRACT

The purpose of this integrated literature review was to determine the extent of research available related to polypharmacy and its effect on the health outcomes of the elderly population. A search of the Cumulative Index of Nursing and Allied Health Literature and Medline was conducted for studies published between 1995 and 2003 that linked polypharmacy and outcomes in the elderly population. The 16 studies in this integrative literature review were conducted in the United States, Canada, Australia, and Europe. Polypharmacy was shown to be a statistically significant predictor of hospitalization, nursing home placement, death, hypoglycemia, fractures, impaired mobility, pneumonia, and malnutrition. The effect of polypharmacy on elderly individuals is significant as demonstrated by this literature review. Nurses are in a unique position to monitor and potentially eliminate adverse effects of a complex medication regimen. Nursing research on polypharmacy and its effects on nursing-sensitive outcomes will help define guidelines for prevention and intervention.

  • Alarcon, T., Barcena, A., Gonzalez-Montalvo, J.I., Penalosa, C, & Salgado, A. (1999). Factors predictive of outcome on admission to an acute geriatric ward. Age and Aging, 28(5), 429-432.

    > Google Scholar
  • American Nurses Association. (1997). Position statement: Polypharmacy and the older adult. Retrieved February 27, 2002, from http://nursingworld.org/readroom/ position/drug/drpoly.htm

    > Google Scholar
  • Bedell, S. E., Jabbour, S., Goldberg, R., Glaser, H., Gobble, S., Young-Xu, Y., Graboys, T.B., & Ravid, S. (2000). Discrepancies in the use of medications: Their extent and predictors in an outpatient practice. Archives of Internal Medicine, 760(4), 2129-2134.

    > Google Scholar
  • Buajordet, L, Ebbesen, J., Erikssen, J., Brors, O., & Hilberg, T. (2001). Fatal adverse drug events: The paradox of drug treatment. Journal of Internal Medicine, 250(A), 327-341.

    > Google Scholar
  • Cohen, I., Rogers, P., Burke, V., & Beilin, LJ. (1998). Predictors of medication use, compliance and symptoms of hypotension in a community-based sample of elderly men and women. Journal of Clinical Pharmacy and Therapeutics, 23, 423-432.

    > Google Scholar
  • Conry, M. (2000). Polypharmacy: Pandora's medicine chest? Geriatric Times, 1(3). Retrieved June 21, 2005, from www. geriatrictimes.com/g001028.html

    > Google Scholar
  • Courtman, B.J., & Stallings, S.B. (1995). Characterization of drug-related problems in elderly patients on admission to a medical ward. The Canadian Journal of Hospital Pharmacy, 48(3), 161-166.

    > Google Scholar
  • Dunn, CM. (2002). Assessing and preventing medication interactions. Home Healthcare Nurse, 20(2), 105-111.

    > Google Scholar
  • Ebbesen, J., Buajordet, L, Erikssen, J., Brors, O., Hilberg, T, Svaar, H., & Sandvik, L. (2001). Drug-related deaths in a department of internal medicine. Archives of Internal Medicine, 161(19), 2317-2323.

    > Google Scholar
  • Flaherty, J.H., Perry, H.M., III, Lynchard, G.S., & Morley, J.E. (2000). Polypharmacy and hospitalization among older home care patients. Journal of Gerontology: Series A, Biological Sciences and Medical Sciences, 55(1 0), M554-M559.

    > Google Scholar
  • Griep, M.I., Mets, TF, Collys, K., PonjaertKristoffersen, L, & Massart, D.L. (2000). Risk of malnutrition in retirement homes elderly persons measured by the "mini-nutritional assessment." Journal of Gerontology: Series A, Biological Sciences and Medical Sciences, 55(2), M57-M63.

    > Google Scholar
  • Incalzi, R.A., Bellia, V., Catalano, F., Scichilone, N., Imperiale, C, Maggi, S., Rengo, F, Salute Respiratoria neh1- Anziano Study (2001). Evaluation of health outcomes in elderly patients with asthma and COPD using disease-specific and generic instruments: The Salute Respiratoria nell'Anziaone (Sa. RA.) study. Chest, 120(3), 734-742.

    > Google Scholar
  • Jacqmin-Gadda, H, Fourrier, A, Commenges, D., & Dartigues, J.F. (1998). Risk factors for fractures in the elderly. Epidemiology, 9(4), 417-423.

    > Google Scholar
  • Jensen, G. L., Friedmann, J.M., Coleman, CD., & Smiciklas-Wright, H. (2001). Screening for hospitalization and nutritional risks among community-dwelling older persons. American Journal of Clinical Nutrition, 74(2), 201-205.

    > Google Scholar
  • Jones, B.A. (1997). Decreasing polypharmacy in clients most at risk. AACN Clinical Issues, 8(4), 627-634.

    > Google Scholar
  • Kaufman, D.W., Kelly, J.P., Rosenberg, L., Anderson TE., & Mitchell, A.A. (2002). Recent patterns of medication use in the ambulatory adult population of the United States: The Slone survey. Journal of the American Medical Association, 287(3), 337-344.

    > Google Scholar
  • Langmore, S.E., Terpenning, M.S., Schork, A., Chen, Y, Murray, JT., Lopatin, D., & Loesche, WJ. (1998). Predictors of aspiration pneumonia: How important is dysphagia? Dysphagia, 13(2), 69-81.

    > Google Scholar
  • Larsen, P.D., & Martin, J.L.H. (1999). Elder care: Polypharmacy and elderly patients. Association of Operating Room Nurses Journal, 69(3), 619,621-622, 625.

    > Google Scholar
  • Lord, S.R., & Menz, H.B. (2002). Physiologic, psychologic, and health predictors of 6minute walk performance in older people. Archives of Physical Medical Rehabilitation, 83(7), 907-911.

    > Google Scholar
  • Mitchell, J., Mathews H.F., Hunt L.M., Cobb, K.H., & Watson, R. W (2001). Mismanaging prescription medications among rural elders: The effects of socioeconomic status, health status, and medication profile indicators. The Gerontologist, 41(3), 348-356.

    > Google Scholar
  • Monane, M., Monane, S., & Semla, T (1997). Optimal medication use in elders: Key to successful aging. The Western Journal of Medicine, 167(4), 233-237.

    > Google Scholar
  • Neary, S., & White, P (2001, November). Tutorial in polypharmacy. In MW. Edmunds, Mastering the basics in drug prescribing. National Conference for Nurse Practitioners, Baltimore, Maryland. Retrieved March 26, 2002, from www.medscape.com/viewarticle/420212

    > Google Scholar
  • Onder, G., Pedone, C, Landi, F, Cesari, M., Vedova, CD., Bernabei, R., & Gambassi, G. (2002). Adverse drug reactions as cause of hospital admissions: Results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA). Journal of the American Geriatrics Society, 50(12), 1962-1968.

    > Google Scholar
  • PoHt, D.F., & Hungler, B.P. (1999). Nursing research: Principles and methods (6th ed.). Philadelphia: Lippincott.

    > Google Scholar
  • Satish, S., Wnograd, CH., Chavez, C, & Bloch, DA. (1996). Geriatric targeting criteria as predictors of survival and health care utilization. Journal of the American Geriatric Society, 44(8), 914-921.

    > Google Scholar
  • Shorr, R.I., Ray, W.A., Daugherty, J.R., & Griffin, M.R. (1997). Incidence and risk factors for serious hypoglycemia in older persons using insulin or sulfonylureas. Archives of Internal Medicine, 157(15), 1681-1686.

    > Google Scholar
  • U.S. Department of Health and Human Services. (2000a). Healthy People 2010. Retrieved June 21, 2005, from www.healthypeople.gov/Document/ tableof contents . h tm#volume 1

    > Google Scholar
  • U.S. Department of Health and Human Services. (2000b). Healthy People 2010 section 17: Medical product safety. Retrieved July 28, from www.healthypeople.gov/document/html/volume2/l 7Medical.htm

    > Google Scholar
  • Veehof, L.J.G., Stewart, R.E., Meyboom-de Jong, B., & Haaijer-Ruskamp, F.M. (1999). Adverse drug reactions and polypharmacy in the elderly in general practice. European Journal of Clinical Pharmacology, 55(7), 533-536.

    > Google Scholar

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