Abstract
Mesenchymal stem cells (MSCs) have been isolated from a variety of human tissues (eg, bone marrow, peripheral blood, muscle, fat, umbilical blood, amniotic fluid, embryonic tissues, and placenta). Placenta-derived MSCs (PDMSCs) have received considerable interest because of their wide availability and absence of ethical concerns. The authors characterized the biological properties, ultrastructure, growth factor production, and osteoblastic differentiation of PDMSCs and investigated their potential as seed cells for bone tissue engineering.
- 1.Finkemeier CG. Bone-grafting and bone-graft substitutes. J Bone Joint Surg Am. 2002; 84(3):454–464. Crossref Medline, Google Scholar
- 2.Kanczler JM, Oreffo RO. Osteogenesis and angiogenesis: the potential for engineering bone. Eur Cell Mater. 2008; 15:100–114. Crossref Medline, Google Scholar
- 3.Zomorodian E, Baghaban Eslaminejad M. Mesenchymal stem cells as a potent cell source for bone regeneration. Stem Cells Int. 2012; 2012:980353. Crossref Medline, Google Scholar
- 4.Perry CR. Bone repair techniques, bone graft, and bone graft substitutes. Clin Orthop Relat Res. 1999; (360):71–86.
10.1097/00003086-199903000-00010 Crossref Medline, Google Scholar - 5.Oppenheim JS, Segal DH, Spitzer DE. Persistent iliac crest donor site pain: independent outcome assessment. Neurosurgery. 2002; 51(3):854–855. Crossref Medline, Google Scholar
- 6.Neman J, Hambrecht A, Cadry C, Jandial R. Stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering. Biologics. 2012; 6:47–57. Medline, Google Scholar
- 7.Ni P, Fu S, Fan M, Preparation of poly(ethylene glycol)/polylactide hybrid fibrous scaffolds for bone tissue engineering. Int J Nanomedicine. 2011; 6:3065–3075. Medline, Google Scholar
- 8.Rahaman MN, Day DE, Bal BS, Bioactive glass in tissue engineering. Acta Biomater. 2011; 7(6):2355–2373.
10.1016/j.actbio.2011.03.016 Crossref Medline, Google Scholar - 9.Cai YZ, Wang LL, Cai HX, Electrospun nanofibrous matrix improves the regeneration of dense cortical bone. J Biomed Mater Res A. 2010; 95(1):49–57. Crossref Medline, Google Scholar
- 10.Wang L, Zou D, Zhang S, Repair of bone defects around dental implants with bone morphogenetic protein/fibroblast growth factor-loaded porous calcium phosphate cement: a pilot study in a canine model. Clin Oral Implants Res. 2011; 22(2):173–181.
10.1111/j.1600-0501.2010.01976.x Crossref Medline, Google Scholar - 11.Rebelatto CK, Aguiar AM, Moretão MP, Dissimilar differentiation of mesenchymal stem cells from bone marrow, umbilical cord blood, and adipose tissue. Exp Biol Med. 2008; 233(7):901–913.
10.3181/0712-RM-356 Crossref, Google Scholar - 12.Panepucci RA, Siufi JL, Silva WA, Comparison of gene expression of umbilical cord vein and bone marrow-derived mes-enchymal stem cells. Stem Cells. 2004; 22(7):1263–1278.
10.1634/stemcells.2004-0024 Crossref Medline, Google Scholar - 13.Shih DT, Lee DC, Chen SC, Isolation and characterization of neurogenic mesenchymal stem cells in human scalp tissue. Stem Cells. 2005; 23(7):1012–1020.
10.1634/stemcells.2004-0125 Crossref Medline, Google Scholar - 14.Hoffman LM, Carpenter MK. Characterization and culture of human embryonic stem cells. Nat Biotechnol. 2005; 23(6):699–708.
10.1038/nbt1102 Crossref Medline, Google Scholar - 15.Rosland GV, Svendsen A, Torsvik A, Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. Cancer Res. 2009; 69(13):5331–5339.
10.1158/0008-5472.CAN-08-4630 Crossref Medline, Google Scholar - 16.Izadpanah R, Kaushal D, Kriedt C, Long-term in vitro expansion alters the biology of adult mesenchymal stem cells. Cancer Res. 2008; 68(11):4229–4238.
10.1158/0008-5472.CAN-07-5272 Crossref Medline, Google Scholar - 17.Draper JS, Smith K, Gokhale P, Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells. Nat Biotechnol. 2004; 22(1):53–54.
10.1038/nbt922 Crossref Medline, Google Scholar - 18.Maitra A, Arking DE, Shivapurkar N, Genomic alterations in cultured human embryonic stem cells. Nat Genet. 2005; 37(10):1099–1103.
10.1038/ng1631 Crossref Medline, Google Scholar - 19.Fukuchi Y, Nakajima H, Sugiyama D, Human placenta-derived cells have mesenchymal stem/progenitor cell potential. Stem Cells. 2004; 22(5):649–658.
10.1634/stemcells.22-5-649 Crossref Medline, Google Scholar - 20.Xiong N, Zhang Z, Huang J, VEGF-expressing human umbilical cord mesenchymal stem cells, an improved therapy strategy for Parkinson’s disease. Gene Ther. 2011; 18(4):394–402.
10.1038/gt.2010.152 Crossref Medline, Google Scholar - 21.Fasouliotis SJ, Schenker JG. Human umbilical cord blood banking and transplantation: a state of the art. Eur J Obstet Gynecol Reprod Biol. 2000; 90(1):13–25.
10.1016/S0301-2115(99)00214-6 Crossref Medline, Google Scholar - 22.Lee JM, Jung J, Lee HJ, Cho KJ, Hwang SG, Kim GJ. Comparison of immunomodulatory effects of placenta mesenchymal stem cells with bone marrow and adipose mesenchymal stem cells. Int Immunopharmacol. 2012; 13(2):219–224.
10.1016/j.intimp.2012.03.024 Crossref Medline, Google Scholar - 23.Kim MJ, Shin KS, Jeon JH, Human chorionic-plate-derived mesenchymal stem cells and Wharton’s jelly-derived mesenchymal stem cells: a comparative analysis of their potential as placenta-derived stem cells. Cell Tissue Res. 2011; 346(1):53–64.
10.1007/s00441-011-1249-8 Crossref Medline, Google Scholar - 24.Fazekasova H, Lechler R, Langford K, Lombardi G. Placenta-derived MSCs are partially immunogenic and less immunomodulatory than bone marrow-derived MSCs. J Tissue Eng Regen Med. 2011; 5(9):684–694.
10.1002/term.362 Crossref Medline, Google Scholar - 25.Hayati AR, Mohamed AE, Tan GC. An immunohistochemical study of Toll-like receptors 2 and 4 in placenta with and without infection. Malays J Pathol. 2010; 32(1):13–19. Medline, Google Scholar
- 26.Beer AE, Sio JO. Placenta as an immunological barrier. Biol Reprod. 1982; 26(1):15–27.
10.1095/biolreprod26.1.15 Crossref Medline, Google Scholar - 27.Flynn A, Finke JH, Loftus MA. Comparison of interleukin 1 production by adherent cells and tissue pieces from human placenta. Immunopharmacology. 1985; 9(1):19–26.
10.1016/0162-3109(85)90042-6 Crossref Medline, Google Scholar - 28.Mortimer RH, Landers KA, Balakrishnan B, Secretion and transfer of the thyroid hormone binding protein transthyretin by human placenta. Placenta. 2012; 33(4):252–256.
10.1016/j.placenta.2012.01.006 Crossref Medline, Google Scholar - 29.Sahraravand M, Järvelä IY, Laitinen P, Tekay AH, Ryynänen M. The secretion of PAPP-A, ADAM12, and PP13 correlates with the size of the placenta for the first month of pregnancy. Placenta. 2011; 32(12):999–1003.
10.1016/j.placenta.2011.10.005 Crossref Medline, Google Scholar - 30.Huang YC, Yang ZM, Chen XH, Isolation of mesenchymal stem cells from human placental decidua basalis and resistance to hypoxia and serum deprivation. Stem Cell Rev. 2009; 5(3):247–255.
10.1007/s12015-009-9069-x Crossref, Google Scholar - 31.Parolini O, Alviano F, Bagnara GP, Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells. Stem Cells. 2008; 26(2):300–311.
10.1634/stemcells.2007-0594 Crossref Medline, Google Scholar - 32.Rebelatto CK, Aguiar AM, Moretao MP, Dissimilar differentiation of mesenchymal stem cells from bone marrow, umbilical cord blood, and adipose tissue. Exp Biol Med. 2008; 233(7):901–913.
10.3181/0712-RM-356 Crossref, Google Scholar - 33.Battula VL, Bareiss PM, Treml S, Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation. Differentiation. 2007; 75(4):279–291.
10.1111/j.1432-0436.2006.00139.x Crossref Medline, Google Scholar - 34.Buttery LD, Bourne S, Xynos JD, Differentiation of osteoblasts and in vitro bone formation from murine embryonic stem cells. Tissue Eng. 2001; 7(1):89–99.
10.1089/107632700300003323 Crossref Medline, Google Scholar - 35.Rosland GV, Svendsen A, Torsvik A, Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. Cancer Res. 2009; 69(13):5331–5339.
10.1158/0008-5472.CAN-08-4630 Crossref Medline, Google Scholar - 36.Grellier M, Ferreira-Tojais N, Bourget C, Bareille R, Guillemot F, Amedee J. Role of vascular endothelial growth factor in the communication between human osteoprogenitors and endothelial cells. J Cell Biochem. 2009; 106(3):390–398.
10.1002/jcb.22018 Crossref Medline, Google Scholar - 37.D’Ippolito G, Schiller PC, Perez-stable C, Cooperative actions of hepatocyte growth factor and 1,25-di-hydroxyvitamin D3 in osteoblastic differentiation of human vertebral bone marrow stromal cells. Bone. 2002; 31(2):269–275.
10.1016/S8756-3282(02)00820-7 Crossref Medline, Google Scholar - 38.Hossain M, Irwin R, Baumann MJ, McCabe LR. Hepatocyte growth factor (HGF) adsorption kinetics and enhancement of osteoblast differentiation on hydroxyapatite surfaces. Biomaterials. 2005; 26(15):2595–2602.
10.1016/j.biomaterials.2004.07.051 Crossref Medline, Google Scholar - 39.Chua KH, Aminuddin BS, Fuzina NH, Ruszymah BH. Interaction between insulin-like growth factor-1 with other growth factors in serum depleted culture medium for human cartilage engineering. Med J Malaysia. 2004; 59(suppl B):7–8. Medline, Google Scholar
- 40.Barros MM, Yamamoto M, Figueiredo MS, Expression levels of CD47, CD35, CD55, and CD59 on red blood cells and signal-regulatory protein-alpha,beta on monocytes from patients with warm autoimmune hemolytic anemia. Transfusion. 2009; 49(1):154–160.
10.1111/j.1537-2995.2008.01936.x Crossref Medline, Google Scholar - 41.Tournamille C, Blancher A, Le Van Kim C, Sequence, evolution and ligand binding properties of mammalian Duffy antigen/receptor for chemokines. Immunogenetics. 2004; 55(10):682–694.
10.1007/s00251-003-0633-2 Crossref Medline, Google Scholar - 42.Fonseca AM, Pereira CF, Porto G, Arosa FA. Red blood cells promote survival and cell cycle progression of human peripheral blood T cells independently of CD58/LFA-3 and heme compounds. Cell Immunol. 2003; 224(1):17–28.
10.1016/S0008-8749(03)00170-9 Crossref Medline, Google Scholar - 43.Czapiga M, Kirk AD, Lekstrom-Himes J. Platelets deliver costimulatory signals to antigen-presenting cells: a potential bridge between injury and immune activation. Exp Hematol. 2004; 32(2):135–139.
10.1016/j.exphem.2003.11.004 Crossref Medline, Google Scholar - 44.Meabed MH, Taha GM, Mohamed SO, El-Hadidy KS. Autoimmune thrombocytopenia: flow cytometric determination of platelet-associated CD154/CD40L and CD40 on peripheral blood T and B lymphocytes. Hematology. 2007; 12(4):301–307.
10.1080/10245330701383957 Crossref Medline, Google Scholar
