Reconstruction Using Expandable Endoprostheses for Skeletally Immature Patients With Sarcoma
Abstract
Expandable endoprostheses have become an acceptable modality to address the issue of limb-length inequality in limb-sparing procedures for skeletally immature patients afflicted with lower extremity bone sarcomas. This study retrospectively analyzed postoperative outcomes and complications for 7 patients (8 limbs) who underwent minimally invasive or noninvasive reconstruction during a 12-year period. Musculoskeletal Tumor Society (MSTS) scores and complication rates were reported. Mean functional outcome (MSTS scores) at final follow-up was 93.3%. Functional outcomes for the noninvasive and minimally invasive expandable prostheses were 97% and 85%, respectively. Complications included temporary peroneal nerve palsy (2 limbs), infection (2 limbs), prosthesis revision (3 limbs), stiffness (3 limbs), and wound healing problems (3 limbs). None of the patients required amputation. Both minimally and noninvasive expandable prostheses appear to be safe and reliable means of reconstruction that permit limb salvage in skeletally immature patients and provide good functional results considering the alternative is above-knee amputation or hip disarticulation. Although complications are frequent (range, 13%–38%), they often can be managed successfully without amputation, thus providing a good quality of life and functional limb. The noninvasive prosthesis may prove to be a more attractive option by potentially negating additional surgeries and reducing infection rates; however, the short-term experience with this prosthesis warrants further investigations with more patients and longer follow-up. [Orthopedics. 2017; 40(1):e157–e163.]
- 1.Jeys L, Abudu A, Grimer R. Expandable prostheses. In: , eds. Operative Techniques in Orthopaedic Surgical Oncology. Philadelphia, PA: Lippincott Williams & Wilkins; 2012:46–54. Google Scholar
- 2.Neel MD, Letson GD. Modular endoprostheses for children with malignant bone tumors. Cancer Control. 2001; 8(4):344–348. Crossref Medline, Google Scholar
- 3.Dotan A, Dadia S, Bickels J, Expandable endoprosthesis for limb-sparing surgery in children: long-term results. J Child Orthop. 2010; 4(5):391–400.
10.1007/s11832-010-0270-x Crossref Medline, Google Scholar - 4.Simon MA, Aschliman MA, Thomas N, Mankin HJ. Limb-salvage treatment versus amputation for osteosarcoma of the distal end of the femur. J Bone Joint Surg Am. 1986; 68(9):1331–1337. Crossref Medline, Google Scholar
- 5.Lewis MM, Pafford J, Spires W. The expandable prosthesis: tumor prosthesis in children. In: , eds. Bone Tumour Management. London, United Kingdom: Butterworths; 1987:177–183. Google Scholar
- 6.Hwang JS, Mehta AD, Yoon RS, Beebe KS. From amputation to limb salvage reconstruction: evolution and role of the endoprosthesis in musculoskeletal oncology. J Orthop Traumatol. 2014; 15(2):81–86.
10.1007/s10195-013-0265-8 Crossref Medline, Google Scholar - 7.Lewis MM, Bloom N, Esquieres EM, Kenan S, Ryniker DM. The expandable prosthesis: an alternative to amputation for children with malignant bone tumors. AORN J. 1987; 46(3):457–470.
10.1016/S0001-2092(07)66457-6 Crossref Medline, Google Scholar - 8.Wilkins RM, Soubeiran A. The Phenix expandable prosthesis: early American experience. Clin Orthop Relat Res. 2001; 382:51–58.
10.1097/00003086-200101000-00009 Crossref, Google Scholar - 9.Neel MD, Wilkins RM, Rao BN, Kelly CM. Early multicenter experience with a noninvasive expandable prosthesis. Clin Orthop Relat Res. 2003; 415:72–81.
10.1097/01.blo.0000093899.12372.25 Crossref, Google Scholar - 10.Saghieh S, Abboud MR, Muwakkit SA, Saab R, Rao B, Haidar R. Seven-year experience of using Repiphysis expandable prosthesis in children with bone tumors. Pediatr Blood Cancer. 2010; 55(3):457–463.
10.1002/pbc.22598 Crossref Medline, Google Scholar - 11.Gupta A, Meswania J, Pollock R, Noninvasive distal femoral expandable endoprosthesis for limb-salvage surgery in paediatric tumours. J Bone Joint Surg Br. 2006; 88(5):649–654.
10.1302/0301-620X.88B5.17098 Crossref Medline, Google Scholar - 12.Picardo NE, Blunn GW, Shekkeris AS, The medium-term results of the Stanmore non-invasive extendible endoprosthesis in the treatment of paediatric bone tumours. J Bone Joint Surg Br. 2012; 94(3):425–430.
10.1302/0301-620X.94B3.27738 Crossref Medline, Google Scholar - 13.Anderson M, Green WT, Messner MB. Growth and predictions of growth in the lower extremities. J Bone Joint Surg Am. 1963; 45:1–14. Crossref Medline, Google Scholar
- 14.Paley D, Bhave A, Herzenberg JE, Bowen JR. Multiplier method for predicting limb-length discrepancy. J Bone Joint Surg Am. 2000; 82(10):1432–1446. Crossref Medline, Google Scholar
- 15.Enneking WF, Dunham W, Gebhardt MC, Malawar M, Pritchard DJ. A system for the functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system. Clin Orthop Relat Res. 1993; 286:241–246. Crossref, Google Scholar
- 16.Ness KK, Neel MD, Kaste SC, A comparison of function after limb salvage with non-invasive expandable or modular prostheses in children. Eur J Cancer. 2014; 50(18):3212–3220.
10.1016/j.ejca.2014.10.005 Crossref Medline, Google Scholar - 17.Ruggieri P, Mavrogenis AF, Pala E, Romantini M, Manfrini M, Mercuri M. Outcome of expandable prostheses in children. J Pediatr Orthop. 2013; 33(3):244–253.
10.1097/BPO.0b013e318286c178 Crossref Medline, Google Scholar - 18.Dominkus M, Krepler P, Schwameis E, Windhager R, Kotz R. Growth prediction in extendable tumor prostheses in children. Clin Orthop Relat Res. 2001; 390:212–220.
10.1097/00003086-200109000-00024 Crossref, Google Scholar - 19.Eckardt JJ, Kabo JM, Kelley CM, Expandable endoprosthesis reconstruction in skeletally immature patients with tumors. Clin Orthop Relat Res. 2000; 373:51–61.
10.1097/00003086-200004000-00008 Crossref, Google Scholar - 20.Grimer RJ, Belthur M, Carter SR, Tillman RM, Cool P. Extendible replacements of the proximal tibia for bone tumours. J Bone Joint Surg Br. 2000; 82(2):255–260.
10.1302/0301-620X.82B2 .9863 Crossref Medline, Google Scholar - 21.Schiller C, Windhager R, Fellinger EJ, Salzer-Kuntschik M, Kaider A, Kotz R. Extendable tumour endoprostheses for the leg in children. J Bone Joint Surg Br. 1995; 77(4):608–614. Crossref Medline, Google Scholar
- 22.Schindler OS, Cannon SR, Briggs TW, Blunn GW. Stanmore custom-made extendible distal femoral replacements: clinical experience in children with primary malignant bone tumours. J Bone Joint Surg Br. 1997; 79(6):927–937.
10.1302/0301-620X.79B6.7164 Crossref Medline, Google Scholar - 23.Henderson ER, Groundland JS, Pala E, Failure mode classification for tumor endoprostheses: retrospective review of five institutions and a literature review. J Bone Joint Surg Am. 2011; 93(5):418–429.
10.2106/JBJS.J.00834 Crossref Medline, Google Scholar - 24.Beebe K, Song KJ, Ross E, Tuy B, Patterson F, Benevenia J. Functional outcomes after limb-salvage surgery and endoprosthetic reconstruction with an expandable prosthesis: a report of 4 cases. Arch Phys Med Rehabil. 2009; 90(6):1039–1047.
10.1016/j.apmr.2008.12.025 Crossref Medline, Google Scholar - 25.Cipriano CA, Gruzinova IS, Frank RM, Gitelis S, Virkus WW. Frequent complications and severe bone loss associated with the Repiphysis expandable distal femoral prosthesis. Clin Orthop Relat Res. 2015; 473(3):831–838.
10.1007/s11999-014-3564-3 Crossref Medline, Google Scholar

