Skip to main content

Abstract

Purpose:

To assess the effects of systemic propranolol on refractive error in infants with periocular capillary hemangiomas.

Methods:

A single-center study of consecutive patients with capillary hemangiomas treated with systemic propranolol. Refractive data were analyzed using Long’s matrix formalism and the methods of Harris and Kaye.

Results:

Seventeen patients were included. At 6 months postoperatively, hemangioma size reduced from 3,214 to 1,806 mm3 (standard deviation: 4,122 to 2,441). Mean refractive error in the affected eye significantly reduced: −1.25/0.38 × 36 (95% confidence intervals: −5.08/1.20 × 90 to 1.64/1.43 × 180, P = .048) with a smaller change (P = .06) in the unaffected eye of −1.01/+0.31 × 3.16 (95% confidence intervals: −4.02/+1.12 × 180 to +1.49/+0.51 × 90).

Conclusions:

Propranolol produced a clinically significant reduction in the infants’ refractive error and anisometropia. The reduction in the total refractive error and anisometropia has not been evident in previous analyses, which have concentrated on the change in the “cylinder” as the principal outcome measure.

[J Pediatr Ophthalmol Strabismus 2014;51(3):165–170.]

  • 1.Jacobs AH, Walton RG. The incidence of birthmarks in the neonate. Pediatrics. 1976; 58:218–222.

    Google Scholar
  • 2.Holmdahl K. Cutaneous hemangiomas in premature and mature infants. Acta Paediatrica. 1955; 44:370–379.10.1111/j.1651-2227.1955.tb04151.x

    CrossrefGoogle Scholar
  • 3.Spraker MK. The vascular lesions of childhood. Dermatologic Clin. 1986; 4:79–87.

    Google Scholar
  • 4.Margileth AM, Museles M. Cutaneous hemangiomas in children. JAMA. 1965; 194:135–138.10.1001/jama.1965.03090180047011

    CrossrefGoogle Scholar
  • 5.Kushner BJ. Local steroid therapy in adnexal hemangioma. Ann Ophthalmol. 1979; 11:1005–1009.

    Google Scholar
  • 6.Spiteri Cornish K, Reddy AR. The use of propranolol in the management of periocular capillary hemangioma: a systematic review. Eye (Lond). 2011; 25:1277–1283.10.1038/eye.2011.164

    CrossrefGoogle Scholar
  • 7.Snir M, Reich U, Siegel R, et al.Refractive and structural changes in infantile periocular capillary hemangioma treated with propranolol. Eye (Lond). 2011; 25:1627–1634.10.1038/eye.2011.233

    CrossrefGoogle Scholar
  • 8.Fabian ID, Ben-Zion I, Samuel C, Spierer A. Reduction in astigmatism using propranolol as first-line therapy for periocular capillary hemangioma. Am J Ophthalmol. 2011; 151:53–58.10.1016/j.ajo.2010.07.022

    CrossrefGoogle Scholar
  • 9.Harris WF. Statistical inference on mean dioptric power: hypothesis testing and confidence regions. Ophthalmic Physiol Opt. 1990; 10:363–372.10.1111/j.1475-1313.1990.tb00883.x

    CrossrefGoogle Scholar
  • 10.Harris WF. Direct, vec and other squares, and sample variance-covariance of dioptric power. Ophthalmic Physiol Opt. 1990; 10:72–80.

    Google Scholar
  • 11.Harris WF. Representation of dioptric power in Euclidean 3-space. Ophthalmic Physiol Opt. 1991; 11:130–136.10.1111/j.1475-1313.1991.tb00212.x

    Crossref MedlineGoogle Scholar
  • 12.Harris WF. Astigmatism. Ophthalmic Physiol Opt. 2000; 20:11–30.10.1016/S0275-5408(99)00040-X

    CrossrefGoogle Scholar
  • 13.Kaye SB. Approximating lens power. Optom Vis Sci. 2009; 86:382–394.10.1097/OPX.0b013e31819895b8

    CrossrefGoogle Scholar
  • 14.Kaye SB. Average focal length and power of a section of any defined surface. J Cataract Refract Surg. 2010; 36:665–670.10.1016/j.jcrs.2009.11.010

    CrossrefGoogle Scholar
  • 15.Kaye SB, Patterson A. Analyzing refractive changes after anterior segment surgery. J Cataract Refract Surg. 2001; 27:50–60.10.1016/S0886-3350(00)00801-4

    CrossrefGoogle Scholar
  • 16.Long WF. A matrix formalism for decentration problems. Am J Optom Physiol Opt. 1976; 53:27–33.10.1097/00006324-197601000-00005

    Crossref MedlineGoogle Scholar
  • 17.Harris WF. Invariance of ophthalmic properties under spherocylindrical transposition. Optom Vis Sci. 1997; 74:459–462.10.1097/00006324-199706000-00032

    CrossrefGoogle Scholar
  • 18.Harris WF. A unified paraxial approach to astigmatic optics. Optom Vis Sci. 1999; 76:480–499.10.1097/00006324-199907000-00024

    CrossrefGoogle Scholar
  • 19.Harris WF. Power vectors versus power matrices, and the mathematical nature of dioptric power. Optom Vis Sci. 2007; 84:1060–1063.10.1097/OPX.0b013e318157acbb

    CrossrefGoogle Scholar
  • 20.Kaye SB. Actual and intended refraction after cataract surgery. J Cataract Refract Surg. 2003; 29:2189–2194.10.1016/S0886-3350(03)00418-8

    CrossrefGoogle Scholar
  • 21.Kaye SB, Harris WF. Analyzing refractive data. J Cataract Refract Surg. 2002; 28:2109–2116.10.1016/S0886-3350(02)01639-5

    Crossref MedlineGoogle Scholar
  • 22.Kaye SB. Objective evaluation of refractive data and astigmatism:quantification and analysis. Eye. 2014; 28:154–161.10.1038/eye.2013.266

    CrossrefGoogle Scholar
  • 23.Sommers Smith SK, Smith DM. Beta blockade induces apoptosis in cultured capillary endothelial cells. In Vitro Cell Dev Biol Anim. 2002; 38:298–304.10.1290/1071-2690(2002)038<0298:BBIAIC>2.0.CO;2

    CrossrefGoogle Scholar
  • 24.Cheng JF, Gole GA, Sullivan TJ, et al.Propranolol in the management of periocular infantile hemangioma. Clin Experiment Ophthal. 2010; 38:7.10.1111/j.1442-9071.2010.02344.x

    CrossrefGoogle Scholar
  • 25.Claerhout I, Buijsrogge M, Delbeke P, et al.The use of propranolol in the treatment of periocular infantile hemangiomas: a review. Br J Ophthalmol. 2011; 95:1199–1202.10.1136/bjo.2010.192245

    CrossrefGoogle Scholar
  • 26.Al Dhaybi R, Superstein R, Milet A, et al.Treatment of periocular infantile hemangiomas with propranolol: case series of 18 children. Ophthalmology. 2011; 118:1184–1188.10.1016/j.ophtha.2010.10.031

    CrossrefGoogle Scholar
  • 27.Kaye SB, Campbell SH, Davey K, Patterson A. A method of assessing the accuracy of surgical techniques in the correction of astigmatism. Br J Ophthalmol. 1992; 76:738–740.10.1136/bjo.76.12.738

    CrossrefGoogle Scholar
  • 28.Patterson A, Kaye SB, O’Donnell NP. A comprehensive method of analysing the results of phoastigmatic refractive keratectomy for the treatment of post-cataract myopic anisometropia. J Cataract Refract Surg. 2000; 26:229–231.10.1016/S0886-3350(99)00362-4

    CrossrefGoogle Scholar
  • 29.Haik BG, Karcioglu ZA, Gordon RA, Pechous BP. Capillary hemangioma (infantile periocular hemangioma). Surv Ophthalmol. 1994; 38:399–426.10.1016/0039-6257(94)90172-4

    CrossrefGoogle Scholar

We use cookies on this site to enhance your user experience. For a complete overview of all the cookies used, please see our privacy policy.

×