LASIK for the Correction of High Hyperopic Astigmatism With Epithelial Thickness Monitoring
Abstract
PURPOSE:
To evaluate outcomes of high hyperopic LASIK using the MEL 80 excimer laser (Carl Zeiss Meditec, Jena, Germany).
METHODS:
Retrospective analysis of 830 consecutive high hyperopic LASIK procedures using the MEL 80 excimer laser and either the VisuMax femtosecond laser (Carl Zeiss Meditec) or zero compression Hansatome microkeratome (Bausch & Lomb, Rochester, NY). Inclusion criteria were attempted hyperopic correction of +4.00 diopters [D] or higher in one axis and corrected distance visual acuity (CDVA) of 20/20 or better. Patients were observed for a minimum of 1 year. Epithelial thickness monitoring by Artemis very high-frequency (VHF) digital ultrasound (ArcScan Inc., Morrison, CO) was used to evaluate potential for further steepening as a re-treatment.
RESULTS:
One-year data were available for 785 eyes. Mean attempted spherical equivalent refraction (SEQ) was +4.52 ± 0.84 D (range: +2.00 to +6.96 D) for the primary treatment and mean cylinder was 1.05 ± 0.86 D (range: 0.00 to 5.25 D). Mean age was 50 ± 12 years (range: 18 to 70 years) and 61% were women. Postoperative SEQ was ±0.50 D in 50% and ±1.00 D in 77% of eyes after primary treatment. After re-treatment, 67% of eyes were within ±0.50 D and 89% were within ±1.00 D. Uncorrected distance visual acuity was 20/20 or better in 76% of eyes after final treatment. One line of CDVA was lost in 25% of eyes and two lines were lost in 0.4%. There was a clinically insignificant but statistically significant decrease (P < .05) in contrast sensitivity (CSV-1000) by less than 1 log unit at 3 and 6 cycles per degree (cpd) and by 1 log unit at 12 and 18 cpd. Diurnal fluctuation in refraction was identified in 2 eyes, proven by VHF digital ultrasound to be due to diurnal epithelial remodeling overnight and unrelated to maximum postoperative keratometry induced.
CONCLUSIONS:
LASIK for hyperopia by cumulative treatment of up to +8.33 D with the MEL 80 excimer laser was found to satisfy accepted criteria for safety, efficacy, and stability when applying specialized protocols, including epithelial monitoring.
[J Refract Surg. 2017;33(5):314–321.]
- 1.Dausch D, Klein R, Schroder E. Excimer laser photorefractive keratectomy for hyperopia. Refract Corneal Surg. 1993; 9:20–28. Link, Google Scholar
- 2.Arbelaez MC, Knorz MC. Laser in situ keratomileusis for hyperopia and hyperopic astigmatism. J Refract Surg. 1999; 15:406–414. Link, Google Scholar
- 3.Esquenazi S, Mendoza A. Two-year follow-up of laser in situ keratomileusis for hyperopia. J Refract Surg. 1999; 15:648–652. Link, Google Scholar
- 4.Argento CJ, Cosentino MJ. Comparison of optical zones in hyperopic laser in situ keratomileusis: 5.9 mm versus smaller optical zones. J Cataract Refract Surg. 2000; 26:1137–1146.
10.1016/S0886-3350(99)00356-9 Crossref Medline, Google Scholar - 5.Cobo-Soriano R, Llovet F, Gonzalez-Lopez F, Domingo B, Gomez-Sanz F, Baviera J. Factors that influence outcomes of hyperopic laser in situ keratomileusis. J Cataract Refract Surg. 2002; 28:1530–1538.
10.1016/S0886-3350(02)01367-6 Crossref Medline, Google Scholar - 6.El-Agha MS, Bowman RW, Cavanagh D, McCulley JP. Comparison of photorefractive keratectomy and laser in situ keratomileusis for the treatment of compound hyperopic astigmatism. J Cataract Refract Surg. 2003; 29:900–907.
10.1016/S0886-3350(02)02039-4 Crossref Medline, Google Scholar - 7.Oral D, Bowman RW, Cavanagh HD, El-Agha MS, Seward MS, McCulley JP. Hyperopic laser-assisted in situ keratomileusis results with LADARVision, Visx Star S2, and Visx Star S3. Eye Contact Lens. 2004; 30:49–53.
10.1097/01.ICL.0000104599.32450.A1 Crossref Medline, Google Scholar - 8.Dausch D, Smecka Z, Klein R, Schroder E, Kirchner S. Excimer laser photorefractive keratectomy for hyperopia. J Cataract Refract Surg. 1997; 23:169–176.
10.1016/S0886-3350(97)80338-0 Crossref Medline, Google Scholar - 9.Kermani O, Schmeidt K, Oberheide U, Gerten G. Hyperopic laser in situ keratomileusis with 5.5-, 6.5-, and 7.0-mm optical zones. J Refract Surg. 2005; 21:52–58. Link, Google Scholar
- 10.Ditzen K, Fiedler J, Pieger S. Laser in situ keratomileusis for hyperopia and hyperopic astigmatism using the Meditec MEL 70 spot scanner. J Refract Surg. 2002; 18:430–434. Link, Google Scholar
- 11.Reinstein DZ, Couch DG, Archer TJ. LASIK for hyperopic astigmatism and presbyopia using micro-monovision with the Carl Zeiss Meditec MEL80. J Refract Surg. 2009; 25:37–58. Link, Google Scholar
- 12.Waring GO, Fant B, Stevens G, Laser in situ keratomileusis for spherical hyperopia and hyperopic astigmatism using the NIDEK EC-5000 excimer laser. J Refract Surg. 2008; 24:123–136. Link, Google Scholar
- 13.Kermani O, Oberheide U, Schmiedt K, Gerten G, Bains HS. Outcomes of hyperopic LASIK with the NIDEK NAVEX platform centered on the visual axis or line of sight. J Refract Surg. 2009; 25(suppl 1):S98–S103. Medline, Google Scholar
- 14.Alio J, Galal A, Ayala MJ, Artola A. Hyperopic LASIK with Esiris/Schwind technology. J Refract Surg. 2006; 22:772–781. Link, Google Scholar
- 15.de Ortueta D, Arba-Mosquera S, Baatz H. Topographic changes after hyperopic LASIK with the SCHWIND ESIRIS laser platform. J Refract Surg. 2008; 24:137–144. Link, Google Scholar
- 16.Arba-Mosquera S, de Ortueta D. LASIK for hyperopia using an aberration-neutral profile with an asymmetric offset centration. J Refract Surg. 2016; 32:78–83.
10.3928/1081597X-20151119-04 Link, Google Scholar - 17.Kanellopoulos AJ, Conway J, Pe LH. LASIK for hyperopia with the WaveLight excimer laser. J Refract Surg. 2006; 22:43–47. Link, Google Scholar
- 18.Kanellopoulos AJ. Topography-guided hyperopic and hyperopic astigmatism femtosecond laser-assisted LASIK: long-term experience with the 400 Hz eye-Q excimer platform. Clin Ophthalmol. 2012; 6:895–901.
10.2147/OPTH.S23573 Crossref Medline, Google Scholar - 19.de Ortueta D, Schreyger FD. Centration on the cornea vertex normal during hyperopic refractive photoablation using videokeratoscopy. J Refract Surg. 2007; 23:198–200. Link, Google Scholar
- 20.Reinstein DZ, Gobbe M, Archer TJ. Coaxially sighted corneal light reflex versus entrance pupil center centration of moderate to high hyperopic corneal ablations in eyes with small and large angle kappa. J Refract Surg. 2013; 29:518–525.
10.3928/1081597X-20130719-08 Link, Google Scholar - 21.Nepomuceno RL, Boxer Wachler BS, Kim JM, Scruggs R, Sato M. Laser in situ keratomileusis for hyperopia with the LADARVision 4000 with centration on the coaxially sighted corneal light reflex. J Cataract Refract Surg. 2004; 30:1281–1286.
10.1016/j.jcrs.2003.10.031 Crossref Medline, Google Scholar - 22.Varley GA, Huang D, Rapuano CJ, Schallhorn S, Boxer Wachler BS, Sugar A. LASIK for hyperopia, hyperopic astigmatism, and mixed astigmatism: a report by the American Academy of Ophthalmology. Ophthalmology. 2004; 111:1604–1617.
10.1016/j.ophtha.2004.05.016 Crossref Medline, Google Scholar - 23.Reinstein DZ, Archer TJ, Gobbe M, Silverman RH, Coleman DJ. Epithelial thickness after hyperopic LASIK: three-dimensional display with Artemis very high-frequency digital ultrasound. J Refract Surg. 2010; 26:555–564.
10.3928/1081597X-20091105-02 Link, Google Scholar - 24.Reinstein DZ, Yap TE, Carp GI, Archer TJ, Gobbe M. Reproducibility of manifest refraction between surgeons and optometrists in a clinical refractive surgery practice. J Cataract Refract Surg. 2014; 40:450–459.
10.1016/j.jcrs.2013.08.053 Crossref Medline, Google Scholar - 25.Reinstein DZ, Carp GI, de Benedictis D, Standardization of LASIK surgical technique evaluated by comparison of procedure time between two experienced surgeons. J Cataract Refract Surg. 2015; 41:1004–1008.
10.1016/j.jcrs.2014.08.039 Crossref Medline, Google Scholar - 26.Reinstein DZ, Gobbe M, Archer TJ, Carp GI. Mechanism for a rare, idiosyncratic complication following hyperopic LASIK: diurnal shift in refractive error due to epithelial thickness profile changes. J Refract Surg. 2016; 32:364–371.
10.3928/1081597X-20160428-05 Link, Google Scholar - 27.Ferrer-Blasco T, Garcia-Lazaro S, Albarran-Diego C, Belda-Salmeron L, Montes-Mico R. Refractive lens exchange with a multifocal diffractive aspheric intraocular lens. Arq Bras Oftalmol. 2012; 75:192–196.
10.1590/S0004-27492012000300009 Crossref Medline, Google Scholar - 28.Hua X, Yuan XY, Song H, Tang X. Long-term results of clear lens extraction combined with piggyback intraocular lens implantation to correct high hyperopia. Int J Ophthalmol. 2013; 6:650–655. Medline, Google Scholar
- 29.Auffarth GU, Brezin A, Caporossi A, Comparison of Nd:YAG capsulotomy rates following phacoemulsification with implantation of PMMA, silicone, or acrylic intra-ocular lenses in four European countries. Ophthalmic Epidemiol. 2004; 11:319–329.
10.1080/09286580490515116 Crossref Medline, Google Scholar - 30.Yonekawa Y, Kim IK. Pseudophakic cystoid macular edema. Curr Opin Ophthalmol. 2012; 23:26–32.
10.1097/ICU.0b013e32834cd5f8 Crossref Medline, Google Scholar - 31.Boberg-Ans G, Villumsen J, Henning V. Retinal detachment after phacoemulsification cataract extraction. J Cataract Refract Surg. 2003; 29:1333–1338.
10.1016/S0886-3350(03)00057-9 Crossref Medline, Google Scholar - 32.Ling R, Cole M, James C, Kamalarajah S, Foot B, Shaw S. Suprachoroidal haemorrhage complicating cataract surgery in the UK: epidemiology, clinical features, management, and outcomes. Br J Ophthalmol. 2004; 88:478–480.
10.1136/bjo.2003.026138 Crossref Medline, Google Scholar - 33.Day AC, Donachie PH, Sparrow JM, Johnston RL. The Royal College of Ophthalmologists' National Ophthalmology Database study of cataract surgery: report 1, visual outcomes and complications. Eye (Lond). 2015; 29:552–560.
10.1038/eye.2015.3 Crossref Medline, Google Scholar - 34.Menezo JL, Peris-Martinez C, Cisneros-Lanuza AL, Martinez-Costa R. Rate of cataract formation in 343 highly myopic eyes after implantation of three types of phakic intraocular lenses. J Refract Surg. 2004; 20:317–324. Link, Google Scholar
- 35.Javaloy J, Alió JL, Iradier MT, Abdelrahman AM, Javaloy T, Borras F. Outcomes of ZB5M angle-supported anterior chamber phakic intraocular lenses at 12 years. J Refract Surg. 2007; 23:147–158. Link, Google Scholar
- 36.Brandt JD, Mockovak ME, Chayet A. Pigmentary dispersion syndrome induced by a posterior chamber phakic refractive lens. Am J Ophthalmol. 2001; 131:260–263.
10.1016/S0002-9394(00)00606-1 Crossref Medline, Google Scholar - 37.Dejaco-Ruhswurm I, Scholz U, Pieh S, Long-term endothelial changes in phakic eyes with posterior chamber intraocular lenses. J Cataract Refract Surg. 2002; 28:1589–1593.
10.1016/S0886-3350(02)01210-5 Crossref Medline, Google Scholar - 38.Ruiz-Moreno JM, Alió JL. Incidence of retinal disease following refractive surgery in 9,239 eyes. J Refract Surg. 2003; 19:534–547. Link, Google Scholar
- 39.Ascaso FJ, Huerva V, Grzybowski A. Epidemiology, etiology, and prevention of late IOL-capsular bag complex dislocation: review of the literature. J Ophthalmol. 2015; 2015:805706. Crossref Medline, Google Scholar
- 40.Yu Y, Hua H, Wu M, Evaluation of dry eye after femtosecond laser-assisted cataract surgery. J Cataract Refract Surg. 2015; 41:2614–2623.
10.1016/j.jcrs.2015.06.036 Crossref Medline, Google Scholar - 41.Guzowski M, Wang JJ, Rochtchina E, Rose KA, Mitchell P. Five-year refractive changes in an older population: the Blue Mountains Eye Study. Ophthalmology. 2003; 110:1364–1370.
10.1016/S0161-6420(03)00465-2 Crossref Medline, Google Scholar - 42.Rocha KM, Vabre L, Chateau N, Krueger RR. Expanding depth of focus by modifying higher-order aberrations induced by an adaptive optics visual simulator. J Cataract Refract Surg. 2009; 35:1885–1892.
10.1016/j.jcrs.2009.05.059 Crossref Medline, Google Scholar - 43.Moore M, Leccisotti A, Grills C, Moore TC. Near visual acuity following hyperopic photorefractive keratectomy in a presbyopic age group. ISRN Ophthalmol. 2012; 2012:310474.
10.5402/2012/310474 Crossref Medline, Google Scholar

