Skip to main content
Ophthalmic Surgery, Lasers and Imaging Retina, 2013;29(8):669–676
Published Online:https://doi.org/10.3928/1542-8877-19980801-11Cited by:4

Abstract

* BACKGROUND AND OBJECTIVE: To evaluate the efficacy of a novel filtering implant, a synthetic meshwork (MESH), with or without heparin or sodium hyaluronate amendment.

* MATERIALS AND METHODS: Eighteen eyes of 18 rabbits received MESH surgery. The eyes were divided into three subgroups. Six eyes received the MESH implant with no modification (group 1), 6 eyes received MESH saturated with heparin (group 2), and 6 eyes received MESH with sodium hyaluronate administration into the anterior chamber during surgery (group 3). Intraocular pressure (IOP) and outflow facility were measured during a period of 6 months.

* RESULTS: The MESH-implanted eyes showed lower IOP and higher outflow facility than control eyes up to postoperative days 119 and 49, respectively (P > .05). Earliest functional failure was seen in group 3 and latest in group 2.

* CONCLUSION: MESH implant surgery showed a long-term efficacy in reducing IOP. The beneficial effects of added heparin were limited. Sodium hyaluronate administration reduced the efficacy of the implant device.

[Ophthaimic Surg Lasers 1998;29:669-676.]

  • 1. Shields M. Filtering surgery. In: Textbook of Glaucoma. Baltimore: Williams & Wilkins; 1992:577-611.

    > Google Scholar
  • 2. Skuta GL, Parrish RK II. Wound healing in glaucoma filtering surgery. Surv Ophthalmol. 1987;32:149-170.

    > Google Scholar
  • 3. Wolner B, Liebmann JM, Sassani JW, Ritch R, Speaker M, Marmor M. Late bleb-related endophthalmitis after trabeculectomy with adjunctive 5-fluorouracil. Ophthalmology. 1991;98:1053-1060.

    > Google Scholar
  • 4. Oram O, Gross RL, Wilhelmus KR, Hoover JA. Necrotizing keratitis following trabeculectomy with mitomycin. Arch Ophthalmol. 1995:113:19-20.

    > Google Scholar
  • 5. Prata JAJr, Seah SKL, Minckler DS, Baerveldt G, Lee PP, Heuer DK. Postoperative complications and shortterm outcome after 5-fluorouracil or mitomycin-C trabeculectomy. / Glaucoma. 1995:4:25-31.

    > Google Scholar
  • 6. Caronia RM, Lîebmann JM, Friedman R, Cohen H, Ritch R. Trabeculectomy at the inferior limbus. Arch Ophthalmol. 1996;! 14:387-391.

    > Google Scholar
  • 7. Schocket SS. Investigations of the reasons for success and failure in the anterior shunt-to-the-encirclingband procedure in the treatment of refractory glaucoma. Trans Am Ophthalmol Soc. 1986;84:743-797.

    > Google Scholar
  • 8. Folberg R, Hargett NA, Weaver JE, McLean IW. Filtering valve implant for neovascular glaucoma in proliferative diabetic retinopathy. Ophthalmology. 1982;89:286-289.

    > Google Scholar
  • 9. Gautier S, Duchesne B, Parel J-M, Lacombe E, Legeais JM, Alfonso E. Porous PTFE membranes for keratoprosthesis: comparison of intracorneal biocompatibility. Invest Ophthalmol Vis Sd. 1996;37:S317.

    > Google Scholar
  • 10. Jallet V, Parel J-M, Matsui T, et al. An artificial trabeculum (MESH) for glaucoma surgery. SPIE Ophthalmic Technologies V 1995;2393:285-290.

    > Google Scholar
  • 11. Matsui T, Sasoh M, Haefliger I, et al. Safety and efficacy of an artificial trabecular meshwork implant (MESH) in rabbits. Invest Ophthalmol Vis Sci. 1995; 36:S412.

    > Google Scholar
  • 12. Jallet V, Gautier SE, Parel J-M, et al. A novel synthetic meshwork for glaucoma treatment: 1. Design and preliminary in vitro and in vivo evaluation of various ePTFE materials. / Biomed Mater Res. In press.

    > Google Scholar
  • 13. Kato H, Parel J-M, Jallet V, et al. Artificial meshwork implant (MESH) for glaucoma filtration surgery. Invest Ophthalmol Vis Sd. 1996;37:S256.

    > Google Scholar
  • 14. Miller MH, Joseph NH, Ennis KW, Grieson I, Hitchings RA. An animal model of filtration surgery. Trans Ophthalmol Soc UK. 1985:104:893-897.

    > Google Scholar
  • 15. Kay JS, Litin BS, Jones MA, Fryczkowski AW, Chvapil M, Herschler J. Delivery of annfibroblast agents as adjuncts to filtration surgery: Part II. Delivery of 5-fluorouracil and bleomycin in a collagen implant: pilot study in the rabbit. Ophthalmic Surg. 1986; 17: 796-801.

    > Google Scholar
  • 16. McGuigan LJB, Cook DJ, Yablonski ME. Dexamethasone, D-Penicillamine, and glaucoma filter surgery in rabbits. Invest OphthaÎmol Vis Sci. 1986; 27:1755-1757.

    > Google Scholar
  • 17. Lee DA, Flores RA, Anderson PJ, et al. Glaucoma filtration surgery in rabbits using bíoerodible polymers and 5-fluorouracil. Ophthalmology. 1987;94: 1523-1530.

    > Google Scholar
  • 18. Lee DA, Leong KW, Panek WC, Eng CT, Glasgow BJ. The use of bioerodible polymers and 5-fluorouracil in glaucoma filtration surgery. Invest Ophthalmol Vis Sd. 1988;29:1692-1697.

    > Google Scholar
  • 19. Fourman S. Effects of aminoproprionitrile on glaucoma filter blebs in rabbits. Ophthalmic Surg. 1988; 19:649-652.

    > Google Scholar
  • 20. Miller MH1 Grierson I, Unger WI, Hitchings RA. Wound healing in an animal model of glaucoma fistulizing surgery in the rabbit. Ophthalmic Surg. 1989;20:350-357.

    > Google Scholar
  • 21. Fourman S1 Vaid K. Effects of tissue plasminogen activator on glaucoma filter blebs in rabbits. Ophthalmic Surg. I989;20:663-667.

    > Google Scholar
  • 22. Miller MH, Grierson I, Unger WG, Hitchings RA. The effect of topical dexamethasone and preoperative beta irradiation on a model of glaucoma fistulîzing surgery in the rabbit. Ophthalmic Surg. 1990; 21:44-54.

    > Google Scholar
  • 23. Wilson MR, Lee DA, Baker RS1 Goodwin LT, Wooten K The effect of topical mitomycin on glaucoma filtration surgery in rabbits. / Ocul Pharmacol. 1991;7:1- 8.

    > Google Scholar
  • 24. Strauss GH, Dunn ET, Dunn RC, Bodiford GB, Christie J. Subco njuncti val high dose plasminogen activator in rabbit filtration surgery. / Ocul Pharmacol. 1991:7:9-19.

    > Google Scholar
  • 25. Bergstrom TJ, Wiîkinson WS, Skuta GL1 Watnick RL, Einer VM. The effects of subco njunctival mitomycinC on glaucoma filtration surgery in rabbits. Arch Ophthalmol. 1991;109:1725-1730.

    > Google Scholar
  • 26. Charles JB, Gambier R Jr, Wilson MR, et al. Use of bioerodible polymers impregnated with mitomycin in glaucoma filtration surgery in rabbits. Ophthalmology. 1991;98:503-508.

    > Google Scholar
  • 27. Khaw PT, Doyle JW, Sherwood MB, Smith MF1 McGorray S. Effects of intraoperative 5-fluorouracil or mitomycin-C on glaucoma filtration surgery in the rabbit. Ophthalmology. 1993;100:367-372.

    > Google Scholar
  • 28. Jampel HD, Morrison J, Vocci M, Quigley H. Identification of fibrin/fibrinogen in glaucoma filtration surgery wounds. Ophthalmic Surg. 1988;19: 576-579.

    > Google Scholar
  • 29. Johnson RN, Blankenship G. A prospective, randomized, clinical trial for postoperative intraocular fibrin. Ophthalmology. 1988;95:312-317.

    > Google Scholar
  • 30. Lundgren B, Ocklind A, Holst A, Harfstrand A. Inflammatory response in the rabbit eye after intraocular implantation with poly(methyl methacrylate) and heparin surface modified intraocular lenses. / Cataract Refract Surg. 1 992; 1 8:65-70.

    > Google Scholar
  • 31. Miller D, Stegmann R. Use of Na- hyal uro nate in autocorneal transplantation in rabbits. Ophthalmic Surg. 1980;11:19-21,

    > Google Scholar
  • 32. Grant W. Tonographic method for measuring the facility and rate of aqueous flow in human eyes. Arch Ophthalmol. 1950;44:204-214.

    > Google Scholar
  • 33. Friedenwald J. Tonometer calibration: an attempt to remove discrepancies found in the 1954 Calibration scale for Schiotz tonometers. Trans Am Acad Ophthalmol Otolaryngol. 1957;6l:108-126.

    > Google Scholar
  • 34. Comander J1 Kato H, Sasoh M, Nose I, Parel J-M. IOP variations during anesthesia in rabbits. Invest Ophthalmol Vis Sd. 1996;37(Suppl):S815.

    > Google Scholar
  • 35. Zeimer R. Orcadian variations in intraocular pressure. In; Ritch R1 Shields MB, Krupin T, eds. The Glaucomas: Basic Sciences. St. Louis: C. V. Mosby; 1996:430-445.

    > Google Scholar
  • 36. Starrels M. The measurement of intraocular pressure. Int Ophthalmol Clin. 1979;19:9-20.

    > Google Scholar
  • 37. Kaufman PL, Davis GE. 'Minified' Goldman applanating prism for tonometry in monkeys and humans. Arch Ophthalmol. 1980;98:542-546.

    > Google Scholar
  • 38. Higginbotham EJ, Kao G, Peyman G. Internal sclerostomy with the Nd:YAG contact laser versus thermal sclerostomy in rabbits. Ophthalmology. 1988;95: 385-390.

    > Google Scholar
  • 39. Karp CL, Higginbotham EJ, Edward DP, Musch DC. Diode laser surgery: ab inferno and ab externo versus conventional surgery in rabbits. Ophthalmology. 1993; 100:1567-1573.

    > Google Scholar
  • 40. Shields SR, Netland PA, Chu JL1 Cotran PR, Kalina PH. Transcorneal erbium laser sclerostomy: towards a guarded laser sclerostomy technique. / Glaucoma. 1995;4:391-397.

    > Google Scholar
  • 41. Cairns JE. Clear-cornea trabeculectomy. Trans Ophthalmol Soc UK. 1985;104:142-145.

    > Google Scholar
  • 42. Weigel PH1 Frost SJ, McGary CT, LeBoeuf RD. The role of hyaluronic acid in inflammation and wound healing. Int J Tiss Reac. 1988;10:355-365.

    > Google Scholar

We use cookies on this site to enhance your user experience. For a complete overview of all the cookies used, please see our privacy policy.

×