EXPERIMENTAL SCIENCE
Trabecular Meshwork Alteration and Intraocular Pressure Change Following Pulsed Near-Infrared Laser Trabeculoplasty in Cats
Ophthalmic Surgery, Lasers and Imaging Retina, 2013;36(6):471–481
Cite this articlePublished Online:November 01, 2005https://doi.org/10.3928/1542-8877-20051101-07Cited by:6
Abstract
* BACKGROUND AND OBJECTIVE: To comparatively assess the safety and variation in intraocular pressure (IOP) of two pulsed near-infrared lasers (titanium:sapphire and alexandrite) for laser trabeculoplasty versus conventional blue-green argon laser trabeculoplasty in an animal model.
* MATERIALS AND METHODS: The left eyes of 15 healthy cats received a 180° laser trabeculoplasty treatment: 5 with a titanium:sapphire laser, 5 with an alexandrite laser, and 5 with an argon laser. Preoperatively and postoperatively, all animals underwent tonometry, gonioscopy, and slit-lamp examination. The cats were observed up to 12 weeks. Scanning electron microscopy and histologic examination were performed to evaluate potential alterations in the trabecular meshwork structure.
* RESULTS: IOP at 1 hour, 1 day, and 1 week following treatment was remarkably lower, irrespective of the laser source used. Following treatment with both near-infrared lasers, gonioscopy showed depigmentation underneath the area of the treated trabecular meshwork and histologic evaluation showed a decrease in pigment density. On scanning electron microscopy, damage to the trabecular meshwork structure could not be detected after treatment with near-infrared lasers.
* CONCLUSIONS: Near-infrared laser trabeculoplasty was found to be effective to temporarily lower IOP in cats. The lasers selectively altered pigment-containing cells, avoiding structural damage of the trabecular meshwork anatomy.
[Ophthalmic Surg Lasers Imaging 2005;36:471-481.]
- 1. Wise JB, Witter SL. Argon laser therapy for open-angle glaucoma. Arch Ophthalmol. 1979;97:319-322. > Google Scholar
- 2. Spaeth GL, Baez KA. Argon laser trabeculoplasty controls one third of cases of progressive, uncontrolled, open angle glaucoma for 5 years. Arch Ophthalmol. 1992;110:491-494. > Google Scholar
- 3. Shingleton BJ, Richter CU, Dharma SK, et al. Longterm efficacy of argon laser trabeculoplasty: a 10-year follow-up study. Ophthalmology. 1993;100:1324-1329. > Google Scholar
- 4. Alexander RA, Grierson I. Morphological effects of argon laser trabeculoplasty upon the glaucomatous human meshwork. Eye. 1989;3:719-726. > Google Scholar
- 5. Koller T, Sturmer J, Reme C, Gloor B. Membrane formation in the chamber angle after failure of argon laser trabeculoplasty: analysis of risk factors. Br J Ophthalmol. 2000;84:48-53. > Google Scholar
- 6. Richter CU, Shingleton BJ, Bellows AR, Hutchinson BT, Jacobson LR Retreatment with argon laser trabeculoplasty. Ophthalmology. 1987;94:1085-1089. > Google Scholar
- 7. Latina MA, Sibayan SA, Shin DH, Noecker RJ, Marcellino G Q-switched 532-nm Nd: YAG laser trabeculoplasty (selective laser trabeculoplasty): a multicenter, pilot, clinical study. Ophthalmology. 1998; 105:20822090. > Google Scholar
- 8. Lanzetta P, Men chini U, Virgili G Immediate intraocular pressure response to selective laser trabeculoplasty. Br J Ophthalmol. 1999;83:29-32. > Google Scholar
- 9. Damji KF, Shah KC, Rock WJ, Bains HS, Hodge WG. Selective laser trabeculoplasty ? argon laser trabeculoplasty: a prospective, randomised clinical trial. Br J Ophthalmol 1999;83:718-722. > Google Scholar
- 10. Gracner T. Intraocular pressure response to selective laser trabeculoplasty in the treatment of primary openangle glaucoma. Ophthalmologica. 2001;215:267-270. > Google Scholar
- 11. Melamed S, Ben Simon GJ, Levkovitch-Verbin H. Selective laser trabeculoplasty as primary treatment for open-angle glaucoma: a prospective, nonrandomized pilot study. Arch Ophthalmol. 2003;121:957-960. > Google Scholar
- 12. Latina MA, Park C. Selective targeting of trabecular meshwork cells: in vitro studies of pulsed and CW laser interactions. Exp Eye Res. 1995;60:359-371. > Google Scholar
- 13. Kramer TR, Noecker RJ. Comparison of the morphologic changes after selective trabeculoplasty and argon laser trabeculoplasty in human eye bank eyes. Ophthalmology. 2001;108:773-779. > Google Scholar
- 14. Manns F, Parel J-M, Fernandez V, et al. Qualitative optical-thermal model of argon, selective, and microsecond infrared laser trabeculoplasty. In: Manns F, Söderberg PG, Ho A, eds. Ophthalmic Technologies XIII: Proceedings of SPIE 2003. Bellingham, WA: International Society for Optical Engineering; 71-76. > Google Scholar
- 15. Simon G, Vivar A, Lowery JA Clinical results following gonioscopic laser trabecular ablation (GLTA) with a Ti:Sapphire laser for the treatment of glaucoma. Invest Ophthalmol Vis Sci. 1995;36:S838. Abstract No. 3861. > Google Scholar
- 16. Vivar A, Lowery J, Restrepo OL, Simon G. A one year follow-up clinical results following gonioscopic laser trabecular ablation (GLTA) with a Ti: Sapphire laser for treatment of glaucoma. Invest Ophthalmol Vis Sci. 1996;37:S263. Abstract No. 1208. > Google Scholar
- 17. Parel JM, Parish RK, Nose I. An intraoperative intraocular pressure monitor. Ophthalmic Res. In press. > Google Scholar
- 18. Stoiber J, Fernandez V, Lamar P, Hitzl W, Fantes F, Parel J-M. Ex-vivo evaluation of Tono-pen and pneumotonometry in cat eyes. Ophthalmic Res. 2006;38:13-18. > Google Scholar
- 19. Rosenberg LF, Karalekas DP, Krupin T, Hyderi A. Cyclocryotherapy and noncontact Nd: YAG laser cyclophotocoagulation in cats. Invest Ophthalmol Vis Sci. 1996;37:2029-2036. > Google Scholar
- 20. Rosenberg LF, Burchfield JC, Krupin T, Bock CJ Jr, Goldenfeld M, O'Grady RB. Cat model for intraocular pressure reduction after transscleral Nd: YAG cyclophotocoagulation. Curr Eye Res. 1995;14:255-261. > Google Scholar
- 21. Van der Zypen E, Frankhauser F. Ultrastructural changes of the trabecular meshwork of the monkey (Macaca speciosa) following irradiation with argon laser light. GraefesArch Clin Exp Ophthalmol. 1984;221:249-261. > Google Scholar
- 22. Melamed S, Pei J, Epstein DL. Short-term effect of argon laser trabeculoplasty in monkeys. Arch Ophthalmol. 1985;103:1546-1552. > Google Scholar
- 23. Melamed S, Pei J, Epstein DL. Delayed response to argon laser trabeculoplasty in monkeys: morphological and morphometric analysis. Arch Ophthalmol. 1986;104:1078-1083. > Google Scholar
- 24. Gaasterland D, Kupfer C. Experimental glaucoma in the rhesus monkey. Invest Ophthalmol Vis Sci. 1974; 14:455457. > Google Scholar
- 25. Quigley HA, Hohman RM. Laser energy levels for trabecular meshwork damage in the primate eye. Invest Ophthalmol Vis Sci. 1983;24:1305-1307. > Google Scholar
- 26. Ticho U. Laser application to the angle structures in animals and in human glaucomatous eyes. Adv Ophthalmol. 1977;34:201-210. > Google Scholar
- 27. Ticho U. Laser application to the angle structures in rabbits, cats, and in human glaucomatous eyes. Doc Ophthalmol. 1977;43:115-125. > Google Scholar
- 28. Wolf J. Trabecular meshwork of the chamber angle in the cat demonstrated by Indian ink injections. Folia Morphologica Cz Acad Sci. 1967;15:287-295. > Google Scholar
- 29. Rodrigues MM, Spaeth GL, Donohoo R Electron microscopy of argon laser therapy in phakic open-angle glaucoma. Ophthalmology. 1982;89:198-210. > Google Scholar
- 30. Weber PA, Davidorf FH, McDonald C. Scanning electron microscopy of argon laser trabeculoplasty. Ophthalmic Forum. 1983;1:26-29. > Google Scholar
- 31. Alexander RA, Grierson I, Church WH. The effect of argon laser trabeculoplasty upon the normal human trabecular meshwork. Graefes Arch Clin Exp Ophthalmol. 1989;227:72-77. > Google Scholar
- 32. Alexander RA, Grierson I. Morphological effects of argon laser trabeculoplasty upon the glaucomatous human meshwork. Eye. 1989;3:719-726. > Google Scholar
- 33. Thomas JV, Simmons RJ, Belcher CD. Complications of argon laser trabeculoplasty. Glaucoma. 1982;4:50. > Google Scholar
- 34. Feller DB, Weinreb RN. Breakdown and reestablishment of blood- aqueous barrier with laser trabeculoplasty. Arch Ophthalmol. 1984;102:537-538. > Google Scholar
- 35. Weinreb RN, Ruderman J, Juster R, Zweig K. Immediate intraocular pressure response to argon laser trabeculoplasty. Am J Ophthalmol. 1983;95:279-286. > Google Scholar
- 36. Schwartz AL, Love DC, Schwartz MA. Long-term follow-up of argon laser trabeculoplasty for uncontrolled open-angle glaucoma. Arch Ophthalmol. 1985; 103:1482-1484. > Google Scholar
- 37. Wise JB. Long term control of adult open angle glaucoma by argon laser treatment. Ophthalmology. 1981;88:197-202. > Google Scholar
- 38. Wickham MG, Worthen DM. Argon laser trabeculotomy: long-term follow-up. Ophthalmology. 1979;86:495503. > Google Scholar
- 39. Weinreb RN, Tsai CS. Laser trabeculoplasty. In: Rich R, Shields MB, Krupin T, eds. The Glaucomas. St. Louis, MO: Mosby-Year Book, Inc.; 1996:1575-1590. > Google Scholar
- 40. Hahnenberger RW Influence of various anesthetic drugs on the intraocular pressure of cats. Albrecht ? Graefes Arch Klin Exp Ophthal. 1 976; 1 99: 1 79- 186. > Google Scholar
- 41. Stoiber J, Fernandez V, Lamar PD, Hitzl W, Fantes F, Parel J-M. Ex-vivo evaluation of Tono-Pen and pneumotonometry in cat eyes. Ophthalmic Res. 2006;38:1318. > Google Scholar
- 42. Bylsma SS, Samples JR, Acott TS, Van Buskirk EM. Trabecular cell division after argon laser trabeculoplasty. Arch Ophthalmol. 1988;106:544-547. > Google Scholar
- 43. Sherwood ME, Richardson TM. Phagocytosis by trabecular meshwork cells: sequence of events in cats and monkeys. Exp Eye Res. 1988;46:881-895. > Google Scholar
- 44. Margolis RJ, Dover JS, Polla LL, et al. Visible action spectrum for melanin-specific selective photothermolysis. Lasers Surg Med. 1989;9:389-397. > Google Scholar
