Abstract
Acute macular neuroretinopathy (AMNR) is a rare condition that primarily affects young women in their reproductive years. Many of the affected young women are on oral contraceptives. Patients report a sudden decrease in visual acuity, usually a few days after the onset of a febrile illness, with paracentral scotomas either unilaterally or bilaterally. Although AMNR was initially thought to be an inner retinal pathology, with the publication of 84 case reports in the English medical literature and the advent of new imaging modalities, it is now thought to be a disease of the outer retina. In 2003, Turbeville et al published a review of more than 41 AMNR cases reported from 1975 to March 2002, which summarized the available literature and suggested potential fields of research to be explored. This article summarizes the 43 case reports that were published in the English literature from April 2002 to October 2012 and also presents a unique case of AMNR.
[Ophthalmic Surg Lasers Imaging Retina. 2015;46:114–124.]
- 1.Bos PM, Deutman AF. Acute macular neuroretinopathy. Am J Ophthalmol. 1975; 80(4):573–584.
10.1016/0002-9394(75)90387-6 Crossref Medline, Google Scholar - 2.Turbeville SD, Cowan LD, Gass JM. Acute macular neuroretinopathy: a review of the literature. Surv Ophthalmol. 2003; 48(1):1–11.
10.1016/S0039-6257(02)00398-3 Crossref Medline, Google Scholar - 3.Chan WM, Liu DL, Tong JP, Law RK, Lam DC. Longitudinal findings of acute macular neuroretinopathy with multifocal electroretinogram and optical coherence tomography. Clin Exp Ophthalmol. 2005; 33(4):439–442.
10.1111/j.1442-9071.2005.01006.x Crossref Medline, Google Scholar - 4.Corver HD, Ruys J, Kestelyn-Stevens AM, De Laey JJ, Leroy BP. Two cases of acute macular neuroretinopathy. Eye. 2007; 21(9):1226–1229.
10.1038/sj.eye.6702543 Crossref Medline, Google Scholar - 5.Baumüller S, Holz FG. Early spectral-domain optical coherence tomography findings in acute macular neuroretinopathy. Retina. 2012; 32(2):409–410.
10.1097/IAE.0b013e31822f573a Crossref Medline, Google Scholar - 6.El-Dairi M, Bhatti MT, Vaphiades MS. A shot of adrenaline. Surv Ophthalmol. 2009: 54(5):618–624.
10.1016/j.survophthal.2009.04.010 Crossref Medline, Google Scholar - 7.Fawzi AA, Pappuru RR, Sarraf D, Acute macular neuroretinopathy: long-term insights revealed by multimodal imaging. Retina. 2012; 32(8):1500–1513.
10.1097/IAE.0b013e318263d0c3 Crossref Medline, Google Scholar - 8.Gelman R, Chen R, Blonska A, Barile G, Sparrow JR. Fundus auto-fluorescence imaging in a patient with rapidly developing scotoma. Retin Cases Brief Rep. 2012; 6(4):345–348.
10.1097/ICB.0b013e318260af5d Crossref Medline, Google Scholar - 9.Grover S, Brar VS, Murthy RK, Chalam KV. Infrared imaging and spectral-domain optical coherence tomography findings correlate with microperimetry in acute macular neuroretinopathy: a case report. J Med Case Rep. 2011; 5:536.
10.1186/1752-1947-5-536 Crossref Medline, Google Scholar - 10.Hashimoto Y, Saito W, Mori S, Saito M, Ishida S. Increased macular choroidal blood flow velocity during systemic corticosteroid therapy in a patient with acute macular neuroretinopathy. Clin Ophthalmol. 2012; 6(1);1645–1649. Medline, Google Scholar
- 11.Hughes EH, Siow YC, Hunyor AP. Acute macular neuroretinopathy: anatomic localisation of the lesion with high-resolution OCT. Eye. 2009; 23(11):2132–2134.
10.1038/eye.2008.430 Crossref Medline, Google Scholar - 12.Maschi C, Schneider-Lise B, Paoli V, Gastaud P. Acute macular neuroretinopathy: contribution of spectral-domain optical coherence tomography and multifocal ERG. Graefes Arch Clin Exp Ophthalmol. 2011; 249(6):827–831.
10.1007/s00417-010-1560-1 Crossref Medline, Google Scholar - 13.Monson BK, Greenberg PB, Greenberg E, High-speed, ultra-high-resolution optical coherence tomography of acute macular neuroretinopathy. Br J Ophthalmol. 2007; 91(1):119–120.
10.1136/bjo.2006.098871 Crossref Medline, Google Scholar - 14.Munch IC, Traustason S, Olgaard K, Larsen M. Acute macular neuroretinopathy in relation to anti-thymocyte globulin infusion. Acta Ophthalmol. 2012; 90(4):321–322.
10.1111/j.1755-3768.2011.02276.x Crossref, Google Scholar - 15.Ranjan P, Hansraj S. Bilateral acute macular neuroretinopathy in a postpartum, otherwise healthy female: a case report. Ind J Ophthalmol. 2012; 60(4):313–315.
10.4103/0301-4738.98713 Crossref Medline, Google Scholar - 16.Rifkin L, Schaal S. Teenage acute macular neuroretinopathy. Eur J Ophthalmol. 2012; 22(4):674–676.
10.5301/ejo.5000076 Crossref Medline, Google Scholar - 17.Vance SK, Spaide RF, Freund KB, Wiznia R, Cooney MJ. Outer retinal abnormalities in acute macular neuroretinopathy. Retina. 2011; 31(3):441–445.
10.1097/IAE.0b013e3181fe54fa Crossref Medline, Google Scholar - 18.Yeh S, Hwang TS, Weleber RG, Watzke RC, Francis PJ. Acute macular outer retinopathy (AMOR): a reappraisal of acute macular neuroretinopathy using multimodality diagnostic testing. Arch Ophthalmol. 2011; 129(3):365–368.
10.1001/archophthalmol.2011.22 Crossref Medline, Google Scholar - 19.Azar G, Wolff B, Cornut P-L, Sahel J-A, Mauget-Faÿsse M. Spectral domain optical coherence tomography evolutive features in acute macular neuroretinopathy. Eur J Ophthalmol. 2012; 22(5):850–852. Crossref Medline, Google Scholar
- 20.Douglas IS, Cockburn DM. Acute macular neuroretinopathy. Clin Exp Optom. 2003; 86(2):121–126.
10.1111/j.1444-0938.2003.tb03070.x Crossref Medline, Google Scholar - 21.Matsuo Y, Uemura A, Nakano T, Inoue M, Sakamoto T. Atypical presentation of acute macular neuroretinopathy with tiny parafoveal reddish-brown lesions. Jpn J Ophthalmol. 2011; 55(4):362–364.
10.1007/s10384-011-0028-0 Crossref Medline, Google Scholar - 22.Shah GK, Cooper BA, Grand MG, Hart WM. Acute macular neuroretinopathy and associated disc swelling and blind spot enlargement. Can J Ophthalmol. 2003; 38(7):602–604.
10.1016/S0008-4182(03)80116-3 Crossref Medline, Google Scholar - 23.Shukla D, Arora A, Ambatkar S, Ramasamy K, Perumalsamy N. Optical coherence tomography findings in acute macular neuroretinopathy. Eye. 2005; 19(1):107–108.
10.1038/sj.eye.6701414 Crossref Medline, Google Scholar - 24.Watzke RC, Shults WT. Annular macular neuroretinopathy and multifocal electroretinographic and optical coherence tomographic findings. Retina. 2004; 24(5):772–775.
10.1097/00006982-200410000-00014 Crossref Medline, Google Scholar - 25.Browning AC, Gupta R, Barber C, Lim CS, Amoaku WM. The multifocal electroretinogram in acute macular neuroretinopathy. Arch Ophthalmol. 2003; 121(10):1506–1507.
10.1001/archopht.121.10.1506 Crossref Medline, Google Scholar - 26.Maturi RK, Yu M, Sprunger DT. Multifocal electroretinographic evaluation of acute macular neuroretinopathy. Arch Ophthalmol. 2003; 121(7):1068–1069.
10.1001/archopht.121.7.1068 Crossref Medline, Google Scholar - 27.Neuhann IM, Inhoffen W, Koerner S, Bartz-Schmidt KU, Gelisken F. Visualization and follow-up of acute macular neuroretinopathy with the Spectralis HRA+OCT device. Graefes Arch Clin Exp Ophthalmol. 2010; 248 (7):1041–1044.
10.1007/s00417-010-1324-y Crossref Medline, Google Scholar - 28.Robert MA, Webster AR, Plant GT. Infrared fundus photography in a case of acute macular neuroretinopathy. Neuroophthalmology. 2008; 32(4):200–202.
10.1080/01658100802274895 Crossref, Google Scholar - 29.Khan IJ, Keane PA, Allie M, Mirza S. Microperimetry and optical coherence tomography in acute macular neuroretinopathy. Retin Cases Brief Rep. 2012; 6(2):202–203.
10.1097/ICB.0b013e3182247729 Crossref Medline, Google Scholar - 30.Yzer S, Bailey Freund K, Engelbert M. Imaging in the diagnosis and management of acute macular neuroretinopathy. Int Ophthalmol Clin. 2012; 52(4);269–273.
10.1097/IIO.0b013e31826704a4 Crossref Medline, Google Scholar - 31.Mirshahi A, Scharioth GB, Klais CC, Baatz H. Enhanced visualization of acute macular neuroretinopathy by Heidelberg Retina Tomography. Clin Exper Ophthalmol. 2006; 34(6):596–599.
10.1111/j.1442-9071.2006.01282.x Crossref Medline, Google Scholar
