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Ophthalmic Surgery, Lasers and Imaging Retina, 2016;47(1):20–26
Published Online:https://doi.org/10.3928/23258160-20151214-03Cited by:47

Abstract

BACKGROUND AND OBJECTIVE:

To evaluate choroidal involvement in acute posterior multifocal placoid pigment epitheliopathy (APMPPE).

PATIENTS AND METHODS:

Retrospective study in five eyes of three patients evaluated through multimodal imaging, including enhanced-depth imaging optical coherence tomography (OCT), ultra-wide field color photography, fundus autofluorescence, and fluorescein angiography (FA). Choroidal thickness and structure were evaluated on OCT.

RESULTS:

During the acute phase, choroidal OCT showed choroidal thickening and a lucency at the level of the inner choroid. Subclinical lesions detected in the retinal periphery using wide-field retinal imaging were isoautofluorescent and corresponded to choriocapillaris filling-defects on FA. At final follow-up, all patients showed resolution of choroidal thickening and the inner choroidal lucency, as well as the disappearance of subclinical lesions.

CONCLUSION:

These results suggest a transient ischemic choroiditis in APMPPE that may lead to secondary permanent retinal pigment epithelium damage in the posterior pole but not in the retinal periphery.

[Ophthalmic Surg Lasers Imaging Retina. 2016;47:20–26.]

  • 1.Gass JD. Acute posterior multifocal placoid pigment epitheliopathy. Arch Ophthalmol. 1968; 80(2):177–185.10.1001/archopht.1968.00980050179005

    > Crossref MedlineGoogle Scholar
  • 2.Deutman AF, Oosterhuis JA, Boen-Tan TN, Aan de Kerk AL. Acute posterior multifocal placoid pigment epitheliopathy. Pigment epitheliopathy of choriocapillaritis?Br J Ophthalmol. 1972; 56(12):863–874.10.1136/bjo.56.12.863

    > Crossref MedlineGoogle Scholar
  • 3.Spaide RF. Autofluorescence imaging of acute posterior multifocal placoid pigment epitheliopathy. Retina. 2006; 26(4):479–482.10.1097/00006982-200604000-00020

    > Crossref MedlineGoogle Scholar
  • 4.Mrejen S, Gallego-Pinazo R, Wald KJ, Freund KB. Acute posterior multifocal placoid pigment epitheliopathy as a choroidopathy: what we learned from adaptive optics imaging. JAMA Ophthalmol. 2013; 131(10):1363–1364.10.1001/jamaophthalmol.2013.4196

    > Crossref MedlineGoogle Scholar
  • 5.Margolis R, Spaide RF. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol. 2009; 147(5):811–815.10.1016/j.ajo.2008.12.008

    > Crossref MedlineGoogle Scholar
  • 6.Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol. 2008; 146(4):496–500.10.1016/j.ajo.2008.05.032

    > Crossref MedlineGoogle Scholar
  • 7.Bird AC, Hamilton AM. Placoid pigment epitheliopathy. Presenting with bilateral serous retinal detachment. Br J Ophthalmol. 1972; 56(12):881–886.10.1136/bjo.56.12.881

    > Crossref MedlineGoogle Scholar
  • 8.Wright BE, Bird AC, Hamilton AM. Placoid pigment epitheliopathy and Harada's disease. Br J Ophthalmol. 1978; 62(9):609–621.10.1136/bjo.62.9.609

    > Crossref MedlineGoogle Scholar
  • 9.Garg S, Jampol LM. Macular serous detachment in acute posterior multifocal placoid pigment epitheliopathy. Retina. 2004; 24(4):650–651.10.1097/00006982-200408000-00031

    > Crossref MedlineGoogle Scholar
  • 10.Goldenberg D, Habot-Wilner Z, Loewenstein A, Goldstein M. Spectral domain optical coherence tomography classification of acute posterior multifocal placoid pigment epitheliopathy. Retina. 2012; 32(7):1403–1410.

    > Crossref MedlineGoogle Scholar
  • 11.Ishihara K, Hangai M, Kita M, Yoshimura N. Acute Vogt-Koyanagi-Harada disease in enhanced spectral-domain optical coherence tomography. Ophthalmology. 2009; 116(9):1799–1807.10.1016/j.ophtha.2009.04.002

    > Crossref MedlineGoogle Scholar
  • 12.Lee GE, Lee BW, Rao NA, Fawzi AA. Spectral domain optical coherence tomography and autofluorescence in a case of acute posterior multifocal placoid pigment epitheliopathy mimicking Vogt-Koyanagi-Harada disease: case report and review of literature. Ocul Immunol Inflamm. 2011; 19(1):42–47.10.3109/09273948.2010.521610

    > Crossref MedlineGoogle Scholar
  • 13.Tanigawa M, Tsukahara Y, Yamanaka H. A case of acute posterior multifocal placoid pigment epitheliopathy demonstrating Vogt-Koyanagi-Harada disease-like optical coherence tomography findings in the acute stage. Case Rep Ophthalmol. 2013; 4(3):172–179.10.1159/000356051

    > Crossref MedlineGoogle Scholar
  • 14.Cheung CM, Yeo IY, Koh A. Photoreceptor changes in acute and resolved acute posterior multifocal placoid pigment epitheliopathy documented by spectral-domain optical coherence tomography. Arch Ophthalmol. 2010; 128(5):644–646.10.1001/archophthalmol.2010.48

    > Crossref MedlineGoogle Scholar

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