Imaging Case Report
Analysis of Scleral Feeder Vessel in Myopic Choroidal Neovascularization Using Optical Coherence Tomography Angiography
Abstract
To describe the appearance of a scleral-derived feeder vessel in a highly myopic eye with secondary choroidal neovascularization (CNV) as visualized on both en face high-speed swept-source (SS) optical coherence tomography angiography (OCTA) prototype, and a commercially available spectral-domain (SD) OCTA, with the corresponding en face and cross-sectional structural OCT images. In this case report, a 60-year-old white male presented with high myopia and secondary CNV in the right eye, previously treated with anti-vascular endothelial growth factor, and was imaged on both SD-OCT and SS-OCT. The neovascular complex could be visualized on both devices. Structural en face SS-OCT images demonstrated a large choroidal-scleral feeder vessel that was not visualized with SD-OCT. The authors concluded that structural en face SS-OCT better visualizes scleral feeder vessel compared to SD-OCT due to the longer wavelength (∼1,050 nm) with increased choroidal penetration and decreased sensitivity roll-off in the SS-OCT system.
[Ophthalmic Surg Lasers Imaging Retina. 2016;47:960–964.]
- 1.Kotsolis AI, Killian FA, Ladas ID, Yannuzzi LA. Fluorescein angiography and optical coherence tomography concordance for choroidal neovascularisation in multifocal choroidtis. Br J Ophthalmol. 2010; 94(11):1506–1508.
10.1136/bjo.2009.159913 Crossref Medline, Google Scholar - 2.Makita S, Hong Y, Yamanari M, Yatagai T, Yasuno Y. Optical coherence angiography. Opt Express. 2006; 14(17):7821–7840.
10.1364/OE.14.007821 Crossref Medline, Google Scholar - 3.Fingler J, Schwartz D, Yang C, Fraser SE. Mobility and transverse flow visualization using phase variance contrast with spectral domain optical coherence tomography. Opt Express. 2007; 15(20):12636–12653.
10.1364/OE.15.012636 Crossref Medline, Google Scholar - 4.Tao YK, Davis AM, Izatt JA. Single-pass volumetric bidirectional blood flow imaging spectral domain optical coherence tomography using a modified Hilbert transform. Opt Express. 2008; 16(16):12350–12361.
10.1364/OE.16.012350 Crossref Medline, Google Scholar - 5.An L, Wang RK. In vivo volumetric imaging of vascular perfusion within human retina and choroids with optical micro-angiography. Opt Express. 2008; 16(15):11438–11452.
10.1364/OE.16.011438 Crossref Medline, Google Scholar - 6.Mariampillai A, Standish BA, Moriyama EH, Speckle variance detection of microvasculature using swept-source optical coherence tomography. Opt Lett. 2008; 33(13):1530–1532.
10.1364/OL.33.001530 Crossref Medline, Google Scholar - 7.Vakoc BJ, Lanning RM, Tyrrell JA, Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Nat Med. 2009; 15(10):1219–1223.
10.1038/nm.1971 Crossref Medline, Google Scholar - 8.Yu L, Chen Z. Doppler variance imaging for three-dimensional retina and choroid angiography. J Biomed Opt. 2010; 15(1):016029.
10.1117/1.3302806 Crossref Medline, Google Scholar - 9.Jonathan E, Enfield J, Leahy MJ. Correlation mapping method for generating microcirculation morphology from optical coherence tomography (OCT) intensity images. J Biophotonics. 2011; 4(9):583–587. Medline, Google Scholar
- 10.Blatter C, Klein T, Grajciar B, Ultrahigh-speed noninvasive widefield angiography. J Biomed Opt. 2012; 17(7):070505.
10.1117/1.JBO.17.7.070505 Crossref Medline, Google Scholar - 11.Jia Y, Tan O, Tokayer J, Split-spectrum amplitudedecorrelation angiography with optical coherence tomography. Opt Express. 2012; 20(4):4710–4725.
10.1364/OE.20.004710 Crossref Medline, Google Scholar - 12.Choi W, Mohler KJ, Potsaid B, Choriocapillaris and choroidal microvasculature imaging with ultrahigh speed OCT angiography. PLoS One. 2013; 8(12):e81499.
10.1371/journal.pone.0081499 Crossref Medline, Google Scholar - 13.Novais EA, Adhi M, Moult EM, Choroidal neovascularization analyzed on ultra-high speed swept source optical coherence tomography angiography compared to spectral domain optical coherence tomography angiography. Am J Ophthalmol. 2016; 164:80–88.
10.1016/j.ajo.2016.01.011 Crossref Medline, Google Scholar - 14.Moult E, Choi W, Waheed NK, Ultrahigh-speed swept-source OCT angiography in exudative AMD. Ophthalmic Surg Lasers Imaging Retina. 2014; 45(6):496–505.
10.3928/23258160-20141118-03 Link, Google Scholar - 15.de Carlo TE, Bonini Filho MA, Chin AT, Spectral-domain optical coherence tomography angiography of choroidal neovascularization. Ophthalmology. 2015; 122(6):1228–1238.
10.1016/j.ophtha.2015.01.029 Crossref Medline, Google Scholar - 16.Rosenfeld PJ, Moshfeghi AA, Puliafito CA. Optical coherence tomography findings after an intravitreal injection of bevacizumab (avastin) for neovascular age-related macular degeneration. Ophthalmic Surg Lasers Imaging. 2005; 36(4):331–335. Link, Google Scholar
- 17.Adhi M, Liu JJ, Qavi AH, Choroidal analysis in healthy eyes using swept-source optical coherence tomography compared to spectral domain optical coherence tomography. Am J Ophthalmol. 2014; 157(6):1272–1281.e1.
10.1016/j.ajo.2014.02.034 Crossref Medline, Google Scholar - 18.Ferrara D, Mohler KJ, Waheed N, En face enhanced-depth swept-source optical coherence tomography features of chronic central serous chorioretinopathy. Ophthalmology. 2014; 121(3):719–726.
10.1016/j.ophtha.2013.10.014 Crossref Medline, Google Scholar - 19.Querques G, Corvi F, Balaratnasingam C, Lacquer cracks and perforating scleral vessels in pathologic myopia: a possible causal relationship. Am J Ophthalmol. 2015; 160(4):759–766.e2.
10.1016/j.ajo.2015.07.017 Crossref Medline, Google Scholar - 20.Klein RM, Green S. The development of lacquer cracks in pathologic myopia. Am J Ophthalmol. 1988; 106(3):282–285.
10.1016/S0002-9394(14)76618-8 Crossref Medline, Google Scholar
